It sounds a bit like the plot of science fiction - wearing a "hat" with electronic components can inhibit the growth of cancer cells in the brain, thus saving the lives of patients with malignant brain cancer. However, the US biotechnology company Novocure Ltd. Turn it into reality. Through a five-year clinical trial, Novocure finally confirmed that this "hat" can effectively help brain cancer patients improve their survival rate - currently, the US FDA has officially approved the sale of this medical device . Killing cancer cells with electric pulses Known as Optune, this "hat" uses an external power supply that continuously delivers electronic pulses of different frequencies to the patient's brain. These special pulse signals, medically known as "tumor treatment fields" (TTFields) - work by inhibiting the proliferation and spread of cancer cells by interfering with the process of cell proliferation and proliferation. This sounds a bit esoteric. Does it feel like you have encountered a "physical therapy device" in the MLM organization? In fact, the latest rise of TTFields, also known as "alternating electric field therapy," is a cancer treatment program recognized by the American medical community, with rigorous scientific principles, and has been confirmed in long-term clinical trials - Novocure is The pioneer of this treatment technology. First, let's review the three main steps of cell division: first, the chromosomes in the cells are arranged in the center of the cell, and second, the microtubules are formed in the cells, and the chromosomes are pulled at a ratio of 1:1. On both sides of the cell, finally, the cell divides from the central region, forming two separate cells. The picture shows the process of cell mitosis, red and white are chromosomes Cells carry charge during the process of division, and these charges help the chromosomes to regularly align and promote the formation of microtubules. That is to say, the electric field plays a key auxiliary role in the process of cell division. It is this characteristic of the cell that TTFields can disturb the electric field itself, so that the cells can not normally perform the first two steps in the process of division. If the chromosomes are abnormally arranged or unevenly distributed, the rate of cell division will slow down and even lead to cell death - which will be a fatal blow to cancer cells. Precision strike, no side effects So, does TTFields affect normal cell division, which can cause serious side effects? The Optune device is only suitable for the treatment of Glioblastomas, which means that the electric field acts directly on the brain without affecting other parts of the body. Cancer cells continue to divide, and most normal cells in the brain do not divide - according to the characteristics of TTFields, it can only act on cells in the process of division, ie cancer cells, without affecting the physiology of normal cells. activity. In other words, Optune uses the characteristics of cancer cells to continue to divide, subtly distinguishing them from normal cells, and hitting them with precision. Clinical trials have shown that patients who are treated do not experience any serious side effects, only mild headaches, and the entire course of treatment does not affect the patient's daily activities. The picture shows the patient receiving Optune treatment
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