Application of Xinyi in the diagnosis of pulmonary tuberculosis

Application of Xinyi in the diagnosis of pulmonary tuberculosis

(Germany IBL original import Item No.: RE59321 Specification: 96T)

Bacterial culture is the gold standard for the diagnosis of tuberculosis, but it takes a long time, generally takes 4 to 8 weeks, and the positive rate of acid-fast bacilli is very low. Since the cellular immune system plays an important role in the pathogenesis of tuberculosis, the determination of some immune indicators such as neopterin is helpful in the diagnosis of tuberculosis.

According to WHO, there are 8 million new cases of tuberculosis each year, and about 3 million patients die from the disease. Bacterial culture is the gold standard for tuberculosis diagnosis, but although the patient's chest X-ray and clinical manifestations are consistent with the diagnostic criteria for tuberculosis, the results of bacterial culture do not confirm that the patient is in the tuberculosis activity, therefore, a non-invasive, Rapid, sensitive, and specific methods for diagnosing tuberculosis. Neopterin is a small molecule compound that is produced by activated T cells and induces the release of monocyte-macrophages. It is a marker reflecting the degree of mononuclear-macrophage activation in vivo. T cells and macrophages are activated during tuberculosis infection, and activated T lymphocytes, especially T helper-1 (TH-1), release γ-interferon, stimulate macrophages to produce new sputum, and are excreted by the kidneys. Therefore, it is possible to diagnose tuberculosis by measuring the level of new fluid in body fluids.

In this regard, Sun Yan, Xu Lianxiu, and Wang Yufen's three teachers (unit: Department of Clinical Laboratory, Chuzhou Central Hospital, Hebei Province) conducted a special study. The results showed that the neobetin levels in serum and urine of patients with pulmonary tuberculosis were significantly higher than those of neonates. In the normal control group, patients with chest X-ray and clinical symptoms have an auxiliary diagnostic effect and can respond to the activity of tuberculosis, thus providing a basis for patients to seek early treatment before the diagnosis of bacterial culture. ( http:// )

Other diagnostic applications for the determination of new sputum are:

l repeated injury ICU patients

l used to predict HIV infection and malignant diseases

l Early prediction of patient complications after transplantation

l indications for autoimmune diseases and disease activities

l diagnosis of viral infection

l differential diagnosis of acute viral and bacterial infections

l Monitoring of chronic infection recurrence and immune stimulation therapy

product name

Catalog number

sample

specification

Brand

Neopterin News

RE59321

Serum, plasma, urine

96T

German IBL

Germany IBL China distributor: Shenzhen Kerunda Biological Engineering Co., Ltd.

Company Address: 7D, No. 45, Yanshan Road, Shekou, Nanshan District, Shenzhen

R&D address: 6th Floor, No. 10, Yanshan Road, Shekou, Nanshan District, Shenzhen

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