Traditional Chinese medicine (natural product) contains proteins, peptides, amino acids, nucleic acids, various enzymes, monosaccharides, oligosaccharides, polysaccharides, glycoproteins, resins, colloids, lignin, vitamins, fats, oils, waxes, alkaloids. , volatile oils, flavonoids, glycosides, terpenoids, phenylpropanoids, organic acids, phenols, terpenes, lactones, steroids, tannins, antibiotics and other natural chemical components. These ingredients can be used as medicines and or foods and their additives. Separating and purifying it from it has always been the direction of human efforts.

It is of great significance to use the appropriate solvent to make the extract as the most basic step of separation. The extract is an important material form in the separation process. The solid content is the main physical property. It reflects the quality of the solid matter in the extract. It can be used to evaluate the transfer of solid components during the extraction process. The balance calculation of the total amount of materials and preparations is one of the indicators for controlling quality.

The initial extract refers to a large amount, the active ingredient content is very low, and it needs to be continuously concentrated or even dried. In the process of concentration and drying, if the relationship between the quality control component and the solid content of the extract is established, the process control of the drying can be linked with the product quality to improve the level of product control.

The first part of the 2010 edition of the Pharmacopoeia (Chinese medicine) Appendix XA Determination of the method of determination of the leachate method - dry weighing method, more used by the industry. Inevitably encountered two shortcomings in the actual operation:

1] Long time required: dry weighing of the weighing bottle, the extract is dried in an oven to constant weight, and cooled in a desiccator. The whole process takes a long time.

2] The representativeness of the results is biased: some extracts, such as volatile oils, volatilize at high temperatures, enzymes lose activity, etc., which inevitably affect the test results.

Based on this, many workers have used the refractometer to test the Brix value (soluble solids) of the leachate, and the quick and easy measurement of the solid content has achieved good results. A refractometer, also known as a refractometer, is an instrument that uses light to test the concentration of a liquid, and measures the concentration of the test solution by converting the relationship between the refractive index of the solution and its concentration. Generally, as the concentration of a substance increases, its refractive index rises commensurately.

Atago, as the leading manufacturer of global refractometers, has been used for 75 years. With its excellent cost performance, Atago has been widely used in pharmaceutical, mechanical processing, chemical and other industries such as beverages and other natural food extraction. The following is a brief introduction to the application of the Atago refractometer in Shanghai Tsumura Pharmaceutical Co., Ltd. Shanghai Tsumura Pharmaceutical Co., Ltd. was established as a joint venture between Tsumura and Shanghai Pharmaceuticals Co., Ltd., and completed the factory in October 2003. It obtained the Chinese pharmaceutical production license in February 2004 and the Chinese pharmaceutical GMP certification in August of the same year. The main product is an extract of the Chinese herbal extract preparation for medical use in Tsumura, Japan - the extract powder, with an annual production scale of about 600T.

Shanghai Jincun Pharmaceutical Co., Ltd. Process Flow Diagram

Extraction and Separation

In the process, the raw materials of the cut raw materials are extracted according to various prescription ingredients of the Chinese preparation, and after being extracted in a hot water boiled state, the extract and the crude drug residue are separated by centrifugation. This process is the most critical process to ensure the quality of the Chinese extract powder.

Concentrated and dry

Before the extract is dried to form a powder, in order to achieve the desired properties of the extract powder, the extract is concentrated to a suitable concentration in advance. In order to avoid the extraction liquid obtained during the extraction process being in a high temperature state for a long time, the low temperature vacuum concentration method is used for concentration .

Detection of Brix values ​​using PR-101a and or Pal-S sampling

Concentrated process pipe installation online refractometer PRM-85

Freeze-dried Powder

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