Within a few years, the transplantable organs needed by the patient will not come from donations from volunteers, but from a printer. This sounds incredible, but doctors at St. Luke's & Roosevelt in New York are working on bioengineered trachea using stem cells and 3D printing. The groundbreaking study was led by Dr. Faiz Bhora, who heads the hospital's thoracic surgery oncology department. Initially, they printed a 3D silica gel model of the trachea—a 4-inch tube that joined the bronchus from the lower end of the throat—and its 3D model was created based on patient CAT scan data. The doctors used a Fab @ Home 3D printer to print the trachea model in about 15 minutes. Dr. Bhora and Dr. Robert Lebovics are co-heads of the Mount Sinai Airway Center in New York, and they are now improving the 3D tracheal model made entirely from biomaterials. Their goal is to be the first artificial trachea implantable in human patients within a few years. Their ultimate goal is to create a customizable organ that will grow with the patient and never need to be replaced. Bhora told reporters that it is almost impossible for patients with inhalation burns, tracheal stenosis or lung disease to achieve organ transplants. There are only a few cases reported around the world, many of which died soon after transplantation. According to the 3D printing information portal Tiangong, many patients can only undergo tracheotomy and then insert a breathing tube, but this will make the patient unable to speak and easily infected. "At the moment, if a person has to replace or transplant a large trachea, there is no good solution at all," Bhora said. "So, in the past few years, we have been trying to find a treatment for these desperate patients." The challenge for any organ transplant is how to respond to the body's immune response to new organs. This problem is especially complicated for organs because it is often exposed to harmful substances when breathing. However, creating an organ with human cells can greatly reduce the risk of rejection - possibly allowing new organs to last longer or even permanently. Using a biogel solution, "we have already done a 3D airway," Bhora said. "The next step is to bind or embed stem cells to differentiate them into cartilage internally, which forms the trachea." “We still need to work hard to try our way to make stem cells grow and replicate reliably.†The research team has seen the dawn of victory, and they successfully implanted a 3D printed tracheal segment into a pig. Three months later, the pig was healthy and could observe the trachea growing with it, Bhora said. This suggests that the goal of implanting bioengineered organs into children who are born without a trachea or other respiratory defects will soon be achieved. Scientists around the world are testing the use of 3D printing technology in the medical field to create stents for organs such as the ear and kidney. Blood vessels and bladders currently made from synthetic materials and stem cells have been successfully implanted in patients' bodies. According to reports, in May last year, scientists were able to print a synthetic pipeline in 3D, successfully avoiding the airway collapse of the baby. In April last year, a 2-year-old girl born without trachea became the first patient to receive a trachea made of plastic fibers and her own cells—although she died of complications several months later. Bhora's team hopes to make the first customizable trachea that does not require chemically synthetic materials, which will hopefully eliminate the need for additional surgery to remove or replace the prosthesis. Calcium Polycarbophil Tablets,Calcium Polycarbophil Tablet,Irritable Bowel Syndrome Tablet,Irritable Bowel Syndrome Drug SHANDONG XINHUA PHARMACEUTICAL Co., Ltd. , https://www.sdxinhuapharm.com