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Determination of Residues of Chemical Synthesis of Antibiotics in Nitrofurans by Liquid Chromatography-Tandem Mass Spectrometry
Food safety analysis workflow
Thermo Scientific Life Science MS not only has a long tradition of technology, but also continues to innovate. Quadrupole mass analysis of true conjugate hyperboloids that fits the perfect theoretical electric field of a textbook is used on all TSQ® triple quadrupole mass spectrometers. Since launching the world's first triple quadrupole MS/MS (TSQ®) mass spectrometer in 1980, TSQ® triple quadrupole mass spectrometer has been widely used in environmental protection, agriculture, quarantine, food safety, etc. Analytical testing, fully capable of testing routine testing of large-volume samples of crops, livestock and poultry products, dairy products and related processed foods, such as pesticide residues in food, veterinary drug residues, mycotoxins, additives, nutritional supplements and organic pollutants And other projects to help you easily meet the increasingly stringent regulatory requirements.
TSQ® Triple Quadrupole Mass Spectrometer and Thermo Fisher Food Safety Testing Strategy
summary
Nitrofuran drugs (Nitrofurans) is a broad spectrum antibiotic, routine testing involving livestock, sausage, fish, honey and other animal-derived sample. Studies have shown that nitrofuran drugs can rapidly decompose in vertebrates, so the method of detecting stable metabolites of such drugs is often used to reflect the residual state of nitrofurans. This article refers to GB/T 20752-2006, GB/T 21166-2007, GB/T 21167-2007, GB/T21311-2007, Ministry of Agriculture No. 781 Announcement-4-2006, Ministry of Agriculture No. 783 Announcement-1-2006, SN /T 1627-2005, SN/T 2061-2008 and other standards, simplified from GB/T 21166-2007, GB/T 21167-2007, Ministry of Agriculture 783 Announcement-1-2006, is a rapid detection of 4 nitrofurans The instrument method for the residual drug amount is quantified by the internal standard method.
Pretreatment
For related reagent materials, standard configuration and reserves, and sample preparation methods, please refer to the above standards. For related instrument methods, please refer to this document. ( TSQ Triple Quadrupole Mass Spectrometer Concise Application Manual - Food Safety Testing )
instrument
The TSQ Triple Quadrupole LC/MS system is equipped with an ultra-high pressure liquid phase system.
Liquid phase condition
Mass spectrometry condition
SRM condition
Experimental result
Typical chromatogram (excerpt from GB/T 21167-2007 appendix)
in conclusion
Among the above national standard detection methods, the detection limit of nitrofuran drugs in different matrices is 0.25-0.5 μg/kg. The method is fully capable of meeting the requirements of domestic and international regulatory standards for sensitivity and reproducibility of conventional regulatory methods.