Skin stem cells produce a human "mini" heart July 17, 2015 Source: Science and Technology Daily American scientists have genetically recombined pluripotent stem cells extracted from human skin to create a micro-ventricle with human heart cells. This "small heart" can behave like a full-sized heart. Researchers say the "mini" organ can replace animal experiments, screen new drugs or test drugs for infants, and will help scientists reveal more of the secrets of human heart formation and development. Kevin Healy, a collaborator of the study and a professor of bioengineering at the University of California at Berkeley, said in an interview with the British Daily Mail on July 15th: "We believe this is the first human micro-ventricle that has been cultivated in test tubes. This technology may help us quickly screen for drugs that may cause fetal heart disease." He and Bruce Conklin, a researcher at the University of California, San Francisco, Gladstone Cardiovascular Institute, used biochemistry and biophysics to promote stem cell differentiation and self-organization into this tiny heart tissue, including the micro-ventricle. Related research is published in the latest issue of Nature Newsletter. To test the potential of the system as a drug screening tool, the researchers exposed the differentiated cells to the drug thalidomide, which could cause severe birth defects. They found that at normal therapeutic doses, the drug caused abnormalities in the development of the microventricular, including shrinking size, muscle contraction, and decreased heart rate. Conklin said: "Each year, about 280,000 pregnant women are exposed to drugs that pose a potential risk to the fetus. The most common birth defects include heart disease. The latest system may significantly reduce the chances of pregnant women coming into contact with toxic drugs. And, despite the latest research The main emphasis is on heart tissue, but new technologies have the potential to produce other body organs." Previously, scientists used cardiomyocytes from experimental mice to study cardiac micro-tissues, but this is not an ideal model for human disease research. The "mini" heart, developed from human stem cells, has revolutionized this practice and will replace animal experiments in the future. Editor-in-chief Under the correct guidance, human pluripotent stem cells can fully develop into designated organ tissues, nerve cells, blood vessels, and even the whole heart. But this is theoretical. In fact, the medical community is far from cultivating the entire human heart. Although the result is only a "mini" heart, it is of great significance to the research in the laboratory, because the body of the primate is much more complicated and more vulnerable than the animals such as experimental mice and experimental rabbits. If you can replace animal experiments, many of the results will become more unprecedented, clear and accurate. Probiotics are a class of active microorganisms that are beneficial to the host by colonizing the human body and changing the composition of the flora in a certain part of the host. By regulating the immune function of the host mucosa and system or by regulating the balance of intestinal flora, promoting nutrient absorption and maintaining intestinal health, resulting in the production of single microorganisms or mixed microorganisms with a well-defined composition that are beneficial to health Probiotics,Acidophilus Lactobacillus,Lactobacillus Acidophilus,Lactobacillus Salivarius SHAANXI HAIBO BIOTECHNOLOGY CO., LTD , https://www.rozenbio.com