Release date: 2017-01-11

The function of mammalian tissues to their physiological functions depends on the support of various nutrients. We know that changes in human metabolites are involved in the pathological process of cancer, but we know very little about which nutrients support the high-speed growth of whole malignant cells.

Amino acids are essential nutrients for most cancer cells. Cancer cells can take extracellular protein metabolites as a source of amino acids through pinocytosis, which is an important source of nutrition for pancreatic cancer cells. However, whether the amino acid nutrient source of this pinocytosis method can maintain the amino acid level in pancreatic cancer cells remains to be further studied.

The team from the Koch Institute of Oncology in the United States labeled albumin with a stable nitrogen isotope and delivered it to mouse liver tissue by plasma exchange. It was found that these albumin metabolites are important amino acids in pancreatic cancer cells. source. The researchers also used a micro-transplant device to deliver these labeled albumin directly into the pancreatic cancer tissue, and observed that the amino acids metabolized by these labeled albumins were directly taken up by the tumor cells through pinocytosis. By inhibiting this pinocytosis of tumor cells with an inhibitor, the level of amino acids in tumor cells can be significantly reduced, thereby inhibiting tumor growth.

Therefore, the drug or gene inhibits the pinocytosis of tumor cells, which can cut off the important nutrient source of tumor cells, and is a potential therapeutic target.

Source: Medical Research (micro-signal researchservice)

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