Swing granulator powder production method:
one,

1. It is very important to prepare soft materials in extrusion granulation. Judging method: making soft materials is a key step in the extrusion granulation. The judgment standard is “hand kneading into a group, lightly pressing and dispersing” or “grip into The group, the light pressure is scattered."

2, powdered sugar and dextrin are commonly used excipients in the preparation of granules, and the ratio of thick paste is generally: thick paste: powdered sugar: the ratio of dextrin is 1:3:1

3. In the preparation of granules, if the soft material is too sticky and the agglomerates are not easy to pass through the screen, it can be solved by adding an appropriate amount of high concentration of ethanol: When the soft material is too soft, the medicinal material fine powder can be added as appropriate; the soft material is too dry and sticky Insufficient amount of binder can be added; soft material must be reduced in viscosity, and high concentration of ethanol can play a role in dispersion. Increasing the amount of feed and tightening the sieve screen will not help solve the problem.

4, general fluidized spray granulation granulation method is mostly used for the preparation of sugar-free and low-sugar granules

5, wine-soluble granules generally use 60% ethanol as a solvent

6. The principle of the treatment of suspended granules is wrong: the medicinal material of the viscous component of sugar should be pulverized into fine powder.

7. The effervescent material of effervescent granules is: A+C

8. The quality requirement for water-soluble granules is that the water content is within 5.0%.

9. Particle size requirements: the total amount of granules and powder that cannot pass through No. 1 sieve and can pass No. 4 sieve shall not exceed 8.0%.

10. Requirements for the solvency of granules: Soluble granules include water-soluble and wine-soluble, and the latter can obviously not dissolve completely.

11. China Pharmacopoeia has detailed regulations on the difference in the loading of granules. How should it be tested: no bag (or bottle) should exceed 1 limit.

two,

1. When the granulation is formed, the soft material forms a mass and it is not easy to press the screen. Reason: The soft material is too sticky

2. When the soft material passes through the screen, the loose material is loose or excessively fine. Reason: The soft material is too dry.

3. When the granulation is easy, the soft material is easy to adhere or the particles are pressed out. The reason is that the soft material is too soft.

4. Preparation of suspension granules with fine powder of medicinal materials as auxiliary material

5, the use of water extraction and alcohol precipitation process is generally used as a preparation of water-soluble granules

6. Preparation of effervescent granules with citric acid as an auxiliary material

7. Drinking wine is a wine-soluble granule

three,

1. Correct understanding of granules: granules refer to dry granular preparations made from medicinal extracts and suitable excipients or medicinal materials; it is developed on the basis of decoctions and syrups; The solid is in a dry state, and the water content is low, so the formulation has good stability, and when it is used, it is boiled with boiling water (or wine), and it is in a liquid state, and the drug is highly dispersed in the solvent and is easily absorbed, so the effect is fast. The 2000 edition of the Chinese Pharmacopoeia contains 29 kinds of traditional Chinese medicine granules.

2. The refining method that can be used in the preparation of water-soluble granules: water extraction and alcohol precipitation is a more widely used method, but the new study by Zui found that the alcohol precipitation process often loses a large amount of active ingredients while removing impurities. Therefore, some new purification methods are being researched continuously, and many good methods have appeared. These methods include high-speed centrifugation, ultrafiltration, flocculation and precipitation, and macroporous adsorption resin.

3, can be used for granulation granulation method: extrusion granulation method is to mix the auxiliary material and the drug thick paste in a suitable container to make the soft material, granulation by extrusion by a swing granulator; rapid mixing granulation The solid auxiliary material, the drug fine powder and the thick paste are co-located in a rapid stirring container, and the material is granulated by adjusting the stirring blade rotation speed to throw the material along the wall by a high-speed rotating granulating knife; the fluidized spray granulation is also called boiling granulation. First, the powder is in a fluidized state, and then the liquid or the binder is intermittently sprayed in a mist, so that the powder is wetted and condensed into porous particles; the dry granulation is to directly press the powder into a thin sheet, and then hit The granules are granulated; the coating pan is granulated by placing the powder in a coating pan and then spraying the granules into the granules.

4. Precautions for drying wet granules in the preparation of granules: If the temperature rises rapidly when the wet granules are dried, the surface of the granules will dry too fast and form a hard shell to affect the internal moisture to continue to evaporate, resulting in the so-called "false dry", in addition to the granules. If the sugar powder melts at a high temperature, the particles become hard, so gradually heat up.

5, wine-soluble granules are generally prepared by impregnation method, percolation method: wine-soluble granules are soluble granules, requiring clarity, the ingredients obtained by boiling method are very polar substances, many are insoluble in certain concentration In ethanol; steam distillation is a method for extracting volatile oil.

6, wine-soluble granules: add rock sugar to taste; to save the medicinal materials can be pulverized into fine powder as an auxiliary material is the preparation of suspension granules when the bulk drug treatment.

7. Effervescent granules: Organic acids and weak bases can neutralize in water, which means that organic acids have been reacted when drinking. The taste is that the generated carbon dioxide is acidic in water and can stimulate the taste buds. Flavor.