Release date: 2016-10-09

Scientists from Harvard Medical School and Massachusetts General Hospital invented instruments that more accurately measure blood glucose levels in diabetic patients over a longer period of time.

Based on the longevity of red blood cells in the patient's body, this new measurement method can more accurately and individually measure the average level of blood glucose in the past 3 months, and its error rate can be compared with our previously used A1c (glycated hemoglobin) test. Reduce by 50%.

Senior researcher John Higgins said: "The standard measurement technology we use most often does not achieve the accuracy it should have. Our research not only points out the root cause, but also provides a new method. A1c detection It is easy to lead to inaccurate measurement results, the research team found that this inaccuracy stems from the individualized differences between red blood cells in the human body.

Scientists have developed a new blood glucose estimation technique that takes into account the red blood cell age factor and measures its accuracy by comparing its results to the results of real-time blood glucose testing on patients.

Experts said: "By estimating the patient's blood glucose levels in the past three months, it is important for us to understand the degree of disease control and the prediction of complications. Persistent hyperglycemia can damage our heart, kidneys, brain, eyes, Other organs such as the brain."

But the body's blood sugar level changes with time. Compared to measuring blood sugar levels at a single time point, getting an average blood glucose level is more valuable for us to understand the level of blood sugar over a period of time. Before we got this blood glucose mean, we usually use A1c test. This method of detection is somewhat inaccurate. Although it is not clear what caused the inaccuracy, scientists have recently suspected that the different "age" of red blood cells is the main factor. Scientists say: "Older red blood cells absorb more glucose than younger red blood cells. So two people with the same actual blood sugar levels will have different blood glucose values ​​because of their different red blood cell ages.

In order to estimate the impact of "different age" red blood cells on the measurement results, scientists invented a calculation formula based on many data. In addition, the scientists also compared the results of this corrected test method and A1c with real-time blood glucose monitors. It was found that the error of our A1c test results is about 16 mg/dl or more, and the improved detection method can greatly reduce this error.

All in all, experts say that the advancement of this technology is also of great significance for the diagnosis, monitoring and treatment of diabetic patients.

Source: Noble

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