New medical hope to develop 3D printed blood vessels and nerve technology August 09, 2016 Source: Kexun
Shandong Chunyu Water-saving Irrigation Equipment Co., Ltd., founded in 2011, is located in Laiwu High-tech Zone, Jinan City. It is a high-tech enterprise focusing on innovative and efficient emitter mold manufacturing and emitter product research and development and production. After nearly ten years of innovation and development, it is the invisible champion enterprise in Shandong Province, and now it is in a leading position in this field in China.
Spring rain people-oriented, build talent highland. At present, the company has 16 high, fine and advanced technical personnel, and cooperates with a number of scientific research institutes, forming a mold design, emitter testing, flow testing and other professional technical personnel team. In recent years, it has obtained 3 invention patents, 33 utility model patents and 3 patent awards. In 2019, it was identified as an intellectual property advantage enterprise in Jinan. It has undertaken 4 provincial science and technology innovation projects and won 2 second prizes of Shandong Science and Technology Progress Award. The company has built Jinan drip emitter mold engineering technology research center, the company has a slow wire cutting, CNC machining center, precision EDM machine, 3D projection measuring instrument, CNC engraving, laser engraving and other advanced processing equipment. Mature technology and rich experience support the excellent quality of Chunyu. Spring Rain pays attention to every link of production, implements 8S management, strictly controls the quality of products at the beginning, the middle and the end, and forms the seamless link of production management. The company has independently researched and developed flat emitter molds with full hot runner, cylindrical emitter molds with full hot runner and other products. With excellent quality, competitive price and good after-sales service, the company is well known at home and abroad, and has been sold well in Egypt, India, Iran, Turkey, Saudi Arabia, the United States and other countries.
With the vision of "building a global professional emitter mold supplier" and the mission of "providing solutions for efficient and innovative production of global water-saving irrigation enterprises", the company takes "scientific and technological innovation to scale new heights; Keep improving, the pursuit of excellence; Honesty and trustworthiness, win-win cooperation "for the values of the enterprise. For the construction of water - saving and resource-saving society to make a positive contribution.
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New medical hope to develop 3D printed blood vessels and nerve technology
At present, in the field of regenerative medicine, many research institutions in Japan are studying the use of 3D printing technology to produce complex tissues such as blood vessels. Saga University in Japan has printed a cell population of iPS cells (human induced pluripotent stem cells) into a tubular structure to form blood vessels. Kyoto University used 3D printing technology to make a nerve-like tubular tissue and transplant it into the experimental mouse to achieve nerve regeneration.
The Japanese government predicts that by 2020, iPS cells will be used to treat diseases such as heart disease, and it is in the process of mastering the artificial three-dimensional tissue transplantation technology similar to the shape of human tissues.
iPS cells are not only used to treat difficult conditions in the eye, but may also be used to treat heart failure and spinal cord injury in the future. Tubular and pocket-like tissue structures often require the use of many cells when culturing long vessels and stereoscopic viscera for transplantation therapy. The research team believes that since the principle of 3D printing technology is to print a layered layer of resin material, if you use cells instead of resin, you can print a three-dimensional structure.
Saga University professor Morita Miki's research team cultured human iPS cells into a group of cells that can develop into blood vessels, and stratified the cells in a multi-row microneedle array of micro-pedestals, and finally printed a length of 2 cm. 5 mm tubular structure.
The tubular structure cells were removed from the fine needle and the culture medium was used internally. Differentiation into different kinds of cells after a few days will form a cell layer on the inner wall, eventually forming blood vessels. Vascular transplantation experiments will be carried out on pigs in the future.
The study used the "Bio3D Printer" developed by Cyfuse, a startup founded by Kyushu University, in collaboration with Silicon Valley Industries.
There is currently a method of treating myocardial infarction in which the patient's other blood vessels are removed to replace the blocked blood vessels. However, this method imposes a great burden on the human body, and the use of artificial blood vessels tends to cause siltation again, so that blood vessels made of iPS cells are expected to be high.
The research team of Kyoto University Associate Professor Chikusuke Ryosuke used a cell that can differentiate into tissues such as skin to make a tubular structure 8 mm long and 3 mm in diameter. It was transplanted into the wound of the experimental mouse with the part of the nerve removed. After 8 weeks, the nerve connection was generated in the tube, and the mouse resumed walking ability. It can be seen that the tubular structure can cultivate cells that grow into nerves and promote nerve regeneration. The technology is put into clinical research after 3 years of planning.