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Baclofen
Baclofen CAS No. 1134-47-0
Baclofen English name: Spinax, Lioresal, Baclofen
Baclofen Drug alias: Ridge Shu, Baclofen, Baclofen, baclofen
Baclofen Chinese alias: Baclofen, Beikang Fen, shellfish can be fun, and the road trip, Lee road trip, Baclofen, chlorobenzene GABA, Buck Nuofen (γ - aminobutyric acidAnalogs).
Baclofen English Name: Baclon, Baclospas, Gabalin, Gabalon, Neurospas, Spastin, Spastion
Character: White or slightly yellowish powder
Standard: USP28
Drug classification: Nervous system drugs - anti-Parkinson's disease and other movement disorders drugs - the anti-drug other movement disorders.
Usage: For severe but reversible muscle spasms caused by multiple sclerosis. Others may apply to: Due to infection, degenerative disease, trauma or tumor-induced spinal spasticity.
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Description
1) Baclofen (brand names Kemstro, Lioresal, Liofen, Gablofen, Lyflex, Beklo and Baclosan) is a derivative of gamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism. It is also used by compounding pharmacies in topical pain creams as a muscle relaxant.
(2) It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups.
(3) A beneficial property of baclofen is that tolerance does not seem to occur to a significant degree - Baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use. Newer studies, however, indicate that tolerance may develop in some patients receiving intrathecal baclofen treatment.
Specifications:
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Items Tested
Specification
Result
Characters
A white, crystalline powder or colorless crystals.
A white crystal.
Identification
IR should comply with the Reference Standard spectrum.
UV should comply with the Reference Standard spectrum.
An orange-red precipitate is performed.
IR complies with the Reference standard spectrum.
UV complies with the Reference standard spectrum.
An orange-red precipitate is performed.
Melting range
88 ~92 degree
89.8-90.2degree
Loss on Drying
Not more than 1.0%
0.22%
Readily carbonizable Substances
The resolution has no more color than Matching Fluid A.
Conform
Residue on ignition
Not more than 0.1%
0.02%
Heavy metals
Not more than 0.001%
Conform
Chloride
Conform
Conform
Assay (HPLC)
98.0%-102.0%
99.5%
Ordinary Impurities
≤1%
Conform
Reaction
Conform
Conform
Conclusion
Complies to USP31
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