Model NO.: 901758-09-6
Product Name: Growth Differentiation Factor 8
MOQ: 1kit
Appearance: Sterile Filtered White Lyophilized Powder
Storage: Dry Cool Place
Trademark: HZ
Transport Package: According to Every Customers′ s Requirements
Specification: 10vials/kit
Origin: China
HS Code: 3001200020
Model NO.: 901758-09-6
Product Name: Growth Differentiation Factor 8
MOQ: 1kit
Appearance: Sterile Filtered White Lyophilized Powder
Storage: Dry Cool Place
Trademark: HZ
Transport Package: According to Every Customers′ s Requirements
Specification: 10vials/kit
Origin: China
HS Code: 3001200020
Gdf 8 Hormone Peptides/Polypeptide Myostatin CAS 901758-09-6Product name: Myostatin GDF-8
Purity: 95%+
Specification: 1mg/vial
Appearance: Sterile Filtered White Lyophilized Powder
Storage: Dry Cool Place
Grade: Medicine Grade
Product Description
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.
Discovery and sequencing
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".
Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
Structure and mechanism of action
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.
Our Advantage:
| Customs clearance | Don't have to worry about customs pass rate,our customs clearance is 100% |
| Product packing | Discreet package .The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration . |
| After-sales service | Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible. |
| Security shipping | Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you. |
| Delivery time | We have stock, so we can delivery quickly at the very day when receive the payment. |
| Condition payment | Western union, money gram, T/T |
Hot Selling Peptides Lists :
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| Product name | Specification | Packing |
| H GH 176-191 | 2mg/vial | 10vials/kit 1g/bag |
| GR RP-2 | 5mg/vial | 10vials/kit 1g/bag |
| GR RP-2 | 10mg/vial | 10vials/kit 1g/bag |
| GR RP-6 | 5mg/vial | 10vials/kit 1g/bag |
| GR RP-6 | 10mg/vial | 10vials/kit 1g/bag |
| MGF | 2mg/vial | 10vials/kit 1g/bag |
| PEG MGF | 2mg/vial | 10vials/kit 1g/bag |
| CJC-1295 with DAC | 2mg/vial | 10vials/kit 1g/bag |
| CJC-1295 without DAC | 2mg/vial | 10vials/kit 1g/bag |
| PT-141 | 10mg/vial | 10vials/kit 1g/bag |
| Melanotan-1 | 10mg/vial | 10vials/kit 1g/bag |
| Melanotan-2 | 10mg/vial | 10vials/kit 1g/bag |
| Ipamorelin | 2mg/vial | 10vials/kit 1g/bag |
| Hexarelin | 2mg/vial | 10vials/kit 1g/bag |
| Sermorelin | 2mg/vial | 10vials/kit 1g/bag |
| Oxytocin | 2mg/vial | 10vials/kit 1g/bag |
| TB500 | 2mg/vial | 10vials/kit 1g/bag |
| Pentadecapeptide BPC 157 | 2mg/vial | 10vials/kit 1g/bag |
| Triptorelin | 2mg/vial | 10vials/kit 1g/bag |
| Gonadorelin | 2mg/vial | 10vials/kit 1g/bag |
| Gonadorelin | 10mg/vial | 10vials/kit 1g/bag |
| Tesamorelin | 2mg/vial | 10vials/kit 1g/bag |
| DSIP | 2mg/vial | 10vials/kit 1g/bag |
| Selank | 5mg/vial | 10vials/kit 1g/bag |
| Adipotide | 1g/foil bag | 1g/foil bag |
| Thyrotropin TRH | 1g/foil bag | 1g/foil bag |
| Epitalon | 10mg/vial | 10vials/kit 1g/bag |
| Deslorelin | 20mg/vial | 10vial/kit 1g/bag |
| Follistatin 315 | 1mg/vial | 1mg/vial 10vials/kit |
| Follistatin 344 | 1mg/vial | 1mg/vial 10vials/kit |
| ACE 031 | 1mg/vial | 1mg/vial 10vials/kit |
| GDF-8 | 1mg/vial | 1mg/vial 10vials/kit |
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If you want to find stable supplier with high quality, competitive price, safe delivery and best sales service,then IÂ am your best choice.
Sky'pe: amydan88
Whats'App: +8618188938027 Gdf 8 Hormone Peptides/Polypeptide Myostatin CAS 901758-09-6
Product name: Myostatin GDF-8
Purity: 95%+
Specification: 1mg/vial
Appearance: Sterile Filtered White Lyophilized Powder
Storage: Dry Cool Place
Grade: Medicine Grade
Product Description
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.
Discovery and sequencing
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".
Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
Structure and mechanism of action
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.
Our Advantage:
| Customs clearance | Don't have to worry about customs pass rate,our customs clearance is 100% |
| Product packing | Discreet package .The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration . |
| After-sales service | Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible. |
| Security shipping | Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you. |
| Delivery time | We have stock, so we can delivery quickly at the very day when receive the payment. |
| Condition payment | Western union, money gram, T/T |
Hot Selling Peptides Lists :
Â
| Product name | Specification | Packing |
| H GH 176-191 | 2mg/vial | 10vials/kit 1g/bag |
| GR RP-2 | 5mg/vial | 10vials/kit 1g/bag |
| GR RP-2 | 10mg/vial | 10vials/kit 1g/bag |
| GR RP-6 | 5mg/vial | 10vials/kit 1g/bag |
| GR RP-6 | 10mg/vial | 10vials/kit 1g/bag |
| MGF | 2mg/vial | 10vials/kit 1g/bag |
| PEG MGF | 2mg/vial | 10vials/kit 1g/bag |
| CJC-1295 with DAC | 2mg/vial | 10vials/kit 1g/bag |
| CJC-1295 without DAC | 2mg/vial | 10vials/kit 1g/bag |
| PT-141 | 10mg/vial | 10vials/kit 1g/bag |
| Melanotan-1 | 10mg/vial | 10vials/kit 1g/bag |
| Melanotan-2 | 10mg/vial | 10vials/kit 1g/bag |
| Ipamorelin | 2mg/vial | 10vials/kit 1g/bag |
| Hexarelin | 2mg/vial | 10vials/kit 1g/bag |
| Sermorelin | 2mg/vial | 10vials/kit 1g/bag |
| Oxytocin | 2mg/vial | 10vials/kit 1g/bag |
| TB500 | 2mg/vial | 10vials/kit 1g/bag |
| Pentadecapeptide BPC 157 | 2mg/vial | 10vials/kit 1g/bag |
| Triptorelin | 2mg/vial | 10vials/kit 1g/bag |
| Gonadorelin | 2mg/vial | 10vials/kit 1g/bag |
| Gonadorelin | 10mg/vial | 10vials/kit 1g/bag |
| Tesamorelin | 2mg/vial | 10vials/kit 1g/bag |
| DSIP | 2mg/vial | 10vials/kit 1g/bag |
| Selank | 5mg/vial | 10vials/kit 1g/bag |
| Adipotide | 1g/foil bag | 1g/foil bag |
| Thyrotropin TRH | 1g/foil bag | 1g/foil bag |
| Epitalon | 10mg/vial | 10vials/kit 1g/bag |
| Deslorelin | 20mg/vial | 10vial/kit 1g/bag |
| Follistatin 315 | 1mg/vial | 1mg/vial 10vials/kit |
| Follistatin 344 | 1mg/vial | 1mg/vial 10vials/kit |
| ACE 031 | 1mg/vial | 1mg/vial 10vials/kit |
| GDF-8 | 1mg/vial | 1mg/vial 10vials/kit |
| Â | Â | Â |
If you want to find stable supplier with high quality, competitive price, safe delivery and best sales service,then IÂ am your best choice.
Sky'pe: amydan88
Whats'App: +8618188938027
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