Myostatin Peptide with High Quality CAS: 901758-09-6 Supply by Lab

October 22, 2018

Model NO.: 901758-09-6
Product Name: Myostatin
Color: White
Form: Powder
Appearance: White Powder
CAS: 901758-09-6
Mf: C221h366n72o67s
Storage: Dry Cool Place
Trademark: Filter
Transport Package: Vial
Specification: 1mg/vial
Origin: China
HS Code: 3001901000
Model NO.: 901758-09-6
Product Name: Myostatin
Color: White
Form: Powder
Appearance: White Powder
CAS: 901758-09-6
Mf: C221h366n72o67s
Storage: Dry Cool Place
Trademark: Filter
Transport Package: Vial
Specification: 1mg/vial
Origin: China
HS Code: 3001901000
Product Description
                          Pharmaceutical  Peptide 99% Purity Myostatin Peptide GDF-8/GDF8
Quick Details
CAS No.: 901758-09-6 Other Names: Myostatin MF: C221H366N72O67S
EINECS No.: N/A Place of Origin: Hubei, China (Mainland) Type: Immune Function Agents, Vitamins, Amino Acids and Coenzymes
Grade Standard: Medicine Grade Usage: Animal Pharmaceuticals    
    Purity: 98%min, 99% Product Name: GDF-8
Chemical Name: Growth Differentiation Factor 8 Appearance: White powder Dry: Freeze
Assay: HPLC 99% Package`: 10 mg/vial Other Name: Myostatin

Description    
  
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.
 
Purity
GDF-8 has a peptide purity level that exceeds 99.0% as determined by HPLC.

Usage
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.

Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

A technique for detecting mutations in myostatin variants has been developed. Mutations that reduce the production of functional myostatin lead to an overgrowth of muscle tissue. Myostatin-related muscle hypertrophy has an incomplete autosomal dominance pattern of inheritance. People with a mutation in both copies of the MSTN gene in each cell (homozygotes) have significantly increased muscle mass and strength. People with a mutation in one copy of the MSTN gene in each cell (heterozygotes) have increased muscle bulk, but to a lesser degree.

In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother has a mutation in one copy of the gene. An American boy born in 2005 was diagnosed with a clinically similar condition but with a somewhat different cause: his body produces a normal level of functional myostatin; but, because he is stronger and more muscular than most others his age, it is believed that a defect in his myostatin receptors prevents his muscle cells from responding normally to myostatin. He appeared on the television show, World's Strongest Toddler.

Further research into myostatin and the myostatin gene may lead to therapies for muscular dystrophy. The idea is to introduce substances that block myostatin. A monoclonal antibody specific to myostatin increases muscle mass in mice and monkeys.

A two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and binds to myostatin, leads to a significantly increased muscle mass (up to 60%). It is thought that binding of myostatin to the soluble activin receptor prevents it from interacting with the cell-bound receptors.

It remains unclear as to whether long-term treatment of muscular dystrophy with myostatin inhibitors is beneficial, as the depletion of muscle stem cells could worsen the disease later on. As of 2012, no myostatin-inhibiting drugs for humans are on the market. An antibody genetically engineered to neutralize myostatin, stamulumab, which was under development by pharmaceutical company Wyeth., is no longer under development. Some athletes, eager to get their hands on such drugs, turn to the internet where fake "myostatin blockers" are being sold.

Myostatin levels are effectively decreased by creatine supplementation.

Inhibition of myostatin leads to muscle hyperplasia and hypertrophy. Myostatin inhibitors can improve athletic performance and therefore there is a concern these inhibitors might be abused in the field of sports. However, studies in mice suggest that myostatin inhibition does not directly increase the strength of individual muscle fibers.

Product List for your reference :
Abarelix Acetate 98% 183552-38-7
Alarelin Acetate 98% 79561-22-1
Angiotensin Acetate 98% 58-49-1
Angiotensin II 98%  68521-88-0
Antide Acetate 98% 112568-12-4
Argpressin Acetate 98% 113-79-1
Argreline Acetate 98%  616204-22-9
Atosiban Acetate 98% 90779-69-4
Aviptadil Acetate 98% 40077-57-4
Bate-Amyloid(1-42)human 95% 107761-42-2
Bivalirudin Trifluoroacetate 98% 128270-60-0
Buserelin acetate 98% 57982-77-1
Calcuitonin   9007/12/9
Carbetocin Acetate 98% 37025-55-1
Carperitide 98%  89213-87-6
Cerropin B 98%  
Cetrorelix Acetate 98% 130143-01-0
Cetrorelix Acetate 98% 130143-01-0
CJC-1295 98%  863288-34-0
Copper Peptide(GHK-Cu) 98% 49557-75-7
CRF (human, rat) Acetate 98% 86784-80-7
CRF (ovine) Trifluoroacetate 98% 79804-71-0
Deslorelin Acetate 98% 57773-65-6
Desmopressin Acetate   98% 16679-58-6
Dynorphin A (1-13) Acetate   98% 72957-38-1
Elcatonin Acetate 98% 60731-46-6
Eledoisin Acetate 98% 69-25-0
Endothelin-1 Acetate 98% 117399-94-7
Enfuvirtide Acetate (T-20) 95% 159519-65-0
Eptifibatide Acetate 98% 148031-34-9/188627-80-7
Exenatide Acetate 98% 141732-76-5
Felypressin Acetate 98% 56-59-7
Fertirelin Acetate 98% 38234-21-8
Ganirelix acetate 98% 123246-29-7
GHRP-2 Acetate 98% 158861-67-7
GHRP-6 Acetate 98% 87616-84-0
Glatiramer Acetate 99% 147245-92-9
GLP(7-36) 98% 107444-51-9
GLP-1 (7-37) Acetate 98% 106612-94-6
Glucagon Hydrochloride 98% 16941-32-5
Gonadorelin Acetate 98% 34973-08-5
Goserelin Acetate 98% 145781-92-6
GRF (human) Acetate 98% 83930-13-6
Hexarelin Acetate 98% 140703-51-1
Histrelin Acetate 98% 76712-82-8
Icatibant Acetate 98% 30308-48-4
Lanreotide 98%  108736-35-2 
Lecirelin (Dalmarelin)  Acetate     98% 61012-19-9
Leuprolide 98%  74381-53-6
Leuprorelin Acetate 98% 53714-56-0
Linaclotide Acatate 98% 851199-59-2
Lixisenatide 98% 320367-13-3
Lraglutide 98% 204656-20-2
Lysipressin Acetate 98% 50-57-7
Melanotan II Acetate 98% 121062-08-6
MOG(35-55) 98% 163913-87-9 
Nafarelin Acetate 98% 76932-56-4
Nesiritide Acetate (BNP-32) 98% 114471-18-0
Octreotide 98% 79517-01-4
Ornipressin Acetate 98% 3397-23-7
Oxytocin Acetate 98% 50-56-6
Palmitoyl Pentapeptide 98% 214047-00-4
Pexiganan 98% 147664-63-9
Pramlintide Acetate 98% 196078-30-5
Pretirelin    
PT141 Acetate 98% 32780-32-8
Salmon Calcitonin Acetate 98% 47931-85-1
Secretin Acetate 98% 10813-74-8
Sermorelin Aceta 98% 86168-78-7
Sincalide 98% 25126-32-3
Somatostatin Acetate 98% 38916-34-6
Splenopentin Acetate 98% 105184-37-0
Taltirelin Acetate 98% 103300-74-9
Teriparatide Acetate 98% 52232-67-4
Teriparatide Acetate 98% 52232-67-4
Terlipressin Acetate   98% 14636-12-5
Tetracosactide Acetate 98% 16960-16-0
Thymalfasin 98% 62304-98-7 
Thymopentin 98% 69558-55-0
Thymosin α1 Acetate 98% 14636-12-5
Thymosin β4 Acetate 98% 77591-33-4
Triptorelin Acetate 98% 57773-63-4
Vapreotide Acetate 98% 103222-11-3
Vasopressin Acetate 98% 9034-50-8
Ziconotide Acetate 98% 107452-89-1

Company Information :
1.Petides: We are the Peptides manufacturer in China.Peptides are all from Labs.We could synthesis in lab whatever you need.
2.Steriods Raw Powder:Our boss have Steriods Raw Powder Facotry in his hometown With 99% Purity only.No cheaper stuff available here.
3.Steriods Oil and Tablets,we have but only sell in Bulk Order or sell together with our Peptides.Not sell seperately. (Mostly are for our Regular Clients only.For Chinese Policies.)
4.Custom-Made Service:If you need our Factory make your own Brands for you, we have Quantity Requirements per time.


Any interest ,please contact Krystal .
Phone :+86-15737953140



  Product Description
                          Pharmaceutical  Peptide 99% Purity Myostatin Peptide GDF-8/GDF8
Quick Details
CAS No.: 901758-09-6 Other Names: Myostatin MF: C221H366N72O67S
EINECS No.: N/A Place of Origin: Hubei, China (Mainland) Type: Immune Function Agents, Vitamins, Amino Acids and Coenzymes
Grade Standard: Medicine Grade Usage: Animal Pharmaceuticals    
    Purity: 98%min, 99% Product Name: GDF-8
Chemical Name: Growth Differentiation Factor 8 Appearance: White powder Dry: Freeze
Assay: HPLC 99% Package`: 10 mg/vial Other Name: Myostatin

Description    
  
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.
 
Purity
GDF-8 has a peptide purity level that exceeds 99.0% as determined by HPLC.

Usage
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.

Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

A technique for detecting mutations in myostatin variants has been developed. Mutations that reduce the production of functional myostatin lead to an overgrowth of muscle tissue. Myostatin-related muscle hypertrophy has an incomplete autosomal dominance pattern of inheritance. People with a mutation in both copies of the MSTN gene in each cell (homozygotes) have significantly increased muscle mass and strength. People with a mutation in one copy of the MSTN gene in each cell (heterozygotes) have increased muscle bulk, but to a lesser degree.

In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother has a mutation in one copy of the gene. An American boy born in 2005 was diagnosed with a clinically similar condition but with a somewhat different cause: his body produces a normal level of functional myostatin; but, because he is stronger and more muscular than most others his age, it is believed that a defect in his myostatin receptors prevents his muscle cells from responding normally to myostatin. He appeared on the television show, World's Strongest Toddler.

Further research into myostatin and the myostatin gene may lead to therapies for muscular dystrophy. The idea is to introduce substances that block myostatin. A monoclonal antibody specific to myostatin increases muscle mass in mice and monkeys.

A two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and binds to myostatin, leads to a significantly increased muscle mass (up to 60%). It is thought that binding of myostatin to the soluble activin receptor prevents it from interacting with the cell-bound receptors.

It remains unclear as to whether long-term treatment of muscular dystrophy with myostatin inhibitors is beneficial, as the depletion of muscle stem cells could worsen the disease later on. As of 2012, no myostatin-inhibiting drugs for humans are on the market. An antibody genetically engineered to neutralize myostatin, stamulumab, which was under development by pharmaceutical company Wyeth., is no longer under development. Some athletes, eager to get their hands on such drugs, turn to the internet where fake "myostatin blockers" are being sold.

Myostatin levels are effectively decreased by creatine supplementation.

Inhibition of myostatin leads to muscle hyperplasia and hypertrophy. Myostatin inhibitors can improve athletic performance and therefore there is a concern these inhibitors might be abused in the field of sports. However, studies in mice suggest that myostatin inhibition does not directly increase the strength of individual muscle fibers.

Product List for your reference :
Abarelix Acetate 98% 183552-38-7
Alarelin Acetate 98% 79561-22-1
Angiotensin Acetate 98% 58-49-1
Angiotensin II 98%  68521-88-0
Antide Acetate 98% 112568-12-4
Argpressin Acetate 98% 113-79-1
Argreline Acetate 98%  616204-22-9
Atosiban Acetate 98% 90779-69-4
Aviptadil Acetate 98% 40077-57-4
Bate-Amyloid(1-42)human 95% 107761-42-2
Bivalirudin Trifluoroacetate 98% 128270-60-0
Buserelin acetate 98% 57982-77-1
Calcuitonin   9007/12/9
Carbetocin Acetate 98% 37025-55-1
Carperitide 98%  89213-87-6
Cerropin B 98%  
Cetrorelix Acetate 98% 130143-01-0
Cetrorelix Acetate 98% 130143-01-0
CJC-1295 98%  863288-34-0
Copper Peptide(GHK-Cu) 98% 49557-75-7
CRF (human, rat) Acetate 98% 86784-80-7
CRF (ovine) Trifluoroacetate 98% 79804-71-0
Deslorelin Acetate 98% 57773-65-6
Desmopressin Acetate   98% 16679-58-6
Dynorphin A (1-13) Acetate   98% 72957-38-1
Elcatonin Acetate 98% 60731-46-6
Eledoisin Acetate 98% 69-25-0
Endothelin-1 Acetate 98% 117399-94-7
Enfuvirtide Acetate (T-20) 95% 159519-65-0
Eptifibatide Acetate 98% 148031-34-9/188627-80-7
Exenatide Acetate 98% 141732-76-5
Felypressin Acetate 98% 56-59-7
Fertirelin Acetate 98% 38234-21-8
Ganirelix acetate 98% 123246-29-7
GHRP-2 Acetate 98% 158861-67-7
GHRP-6 Acetate 98% 87616-84-0
Glatiramer Acetate 99% 147245-92-9
GLP(7-36) 98% 107444-51-9
GLP-1 (7-37) Acetate 98% 106612-94-6
Glucagon Hydrochloride 98% 16941-32-5
Gonadorelin Acetate 98% 34973-08-5
Goserelin Acetate 98% 145781-92-6
GRF (human) Acetate 98% 83930-13-6
Hexarelin Acetate 98% 140703-51-1
Histrelin Acetate 98% 76712-82-8
Icatibant Acetate 98% 30308-48-4
Lanreotide 98% Red Jun Jujube

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