Spider dedicated to human gifts, spider silk research leads medical transplantation into the "silk age"

The spider silk is an extraordinary material. Although it is extremely soft, a pound of spider silk is much stronger than a pound of steel. When the spider silk is spit out, it is a liquid protein that quickly condenses into a solid and is woven into a network of various structures. Spider webs are not only efficient, but also consume less energy. Many spiders can eat the old nets repeatedly and spit out new silk to renovate them.

Oxford University zoologist Fritz Wallace has been researching spiders for 40 years, and he hopes to create silk with mysterious properties for medical care, transplantation and regenerative medicine to better serve humans. . As early as 1976, Wallace published the first paper on spiders, and then published a series of breakthrough studies to explore the unique nature and function of the spider web. In order to study more spiders on the ground, he traveled the world, including the Panamanian Islands and Papua New Guinea, to track exotic species with rare characteristics.

Spider silk research leads medical transplantation into the "wire age"

A fake silk clothing made by a Japanese company, Spiber

Since ancient Greece, people have used the tradition of spider webs to clean up wounds, thinking that this can stop bleeding and prevent infection. Wallace experimented with this approach. They used spider webs to attach to a variety of animal wounds and found that the spider silk perfectly blends with the tissue.

Wares said: "The spider silk is naturally biocompatible, so the wound does not exclude it." The spider silk can also be biodegraded, which indicates that the spider silk bound to the wound is absorbed by the tissue as the wound heals. “Even the less clean silk taken from the spider web has the effect of healing the wound and there is no need to remove them afterwards.”

Synthesize new materials by spider silk code

Wallace's analysis of spider silk found that spider silk protein has a unique pattern of alignment, which is the source of high strength and toughness, making it resistant to stress and deformation. Wallace found that the Golden Orb Weaver spider can spit out seven different types of silk, each with different uses, of which the traction wire used for suspension has the highest strength. Using this kind of traction wire as a model, it is expected to develop a new biomedical implant with super high strength and endurance like a spider silk as a substitute for traditional implants.

But Walles pointed out that this has to solve the problem of production supply. Because it is impossible to make a large number of spider silks, spiders are carnivores and cannot be raised on a large scale. They can only extract one silk at a time. To this end, they turned their attention to silk. Human silkworms have been producing silk products for more than 5,000 years. Through industrial breeding, the annual production of silk can reach 150,000 tons. But the fly in the ointment is that silk is not as strong as spider silk, but also contains a kind of toxic glue, which is not ideal for medical operation.

After becoming the president of Oxford University Silk Group, Wallace discovered a wild silkworm with a similar structure of spit silk and spider silk protein. He sequenced the silk protein and compared it with the protein structure of the spider wire, then dissolved the silk, removed the toxic glue, and reorganized into a high-strength cleaning material named Spidex. silk). The results of the Silk Group attracted the interest of a large number of business people, for which Volleys founded the Oxford Biomaterials Textile Company to develop commercial applications of spider silk.

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