Crack the flu prevention and treatment "card neck" problem May 15, 2018 Source: Science and Technology Daily ——The story behind the development of anti-influenza drug oseltamivir phosphate In the past few days, the flu has once again become a hot word in the Internet, and Bill Gates has announced that he will invest another $12 million to develop new influenza drugs. The seemingly common influenza virus has high variability, rapid spread, and great harm. Even after entering the 21st century, every flu outbreak, health institutions in all countries are waiting. Many people have questions. What is the strength of China in the field of influenza prevention? Can the development of anti-influenza drugs meet people's needs? Recently, the Science and Technology Daily reporter learned from the press conference of the 60th anniversary of the establishment of a pharmaceutical research institute of the Military Medical Research Institute of the Academy of Military Sciences that the anti-influenza drug oseltamivir, which is mainly researched by the Institute, can meet the conventional needs and strategic reserves of China. And the price is only half of the imported drugs, which has occupied nearly 80% of the market share in China. Oseltamivir phosphate is known as the "medicine" against influenza virus, but it is little known that this drug has become a "card neck" drug, which is a prospective study conducted by the researchers. Only to break this bottleneck. In the field of medical protection, this research institute is famous. The research project with the cutting-edge results of the Institute as an important part has won the National Science and Technology Progress Special Award together with the “Two Bombs and One Starâ€. It is this accumulation that allows them to "win one stroke" at the critical moment of national emergency rescue and major epidemic prevention and control. In the spring of 2003, the SARS virus was raging. Recalling the situation at the time, the experts of the institute said to the media: "We realized that the reason why 'SARS' spreads rapidly and is difficult to control, and the lack of effective prevention and treatment drugs is an important reason, and the flu is the most likely to come suddenly in the next round. The major epidemic, as a military medical research worker, has the responsibility to fully prepare for this and create a medical protective shield for the country." Therefore, the researcher Li Song led the research team to take the influenza virus as the key research direction and self-raised funds for drug pre-research. In 2005, H5N1 avian flu once again revealed the face of pandemic diseases. In view of the grim situation, China has no independent anti-influenza drugs produced by China. The Chinese government has urgently approached foreign pharmaceutical companies, but the answer is: 4 years later! At the critical moment of this "card neck", this research institute unexpectedly became the "Mr. Key": the self-developed anti-influenza virus drug - "Army Ove" completed all pre-clinical work. The relevant state departments urgently convened an on-site meeting and decided to assist the country in building an anti-influenza drug production line and complete the strategic reserve task of the country and the army of 500,000 people. The R&D team has been fighting for more than 100 days and nights, and has successively crossed 17 process thresholds to build a production line with an annual production capacity of 2 million. The researcher of the institute said: "The R&D team has taken a unique approach and improved the key production processes that limit the production capacity of foreign companies, which not only improved the production efficiency by three times, but also completely avoided the drawbacks of the original process being prone to explosion and prone to carcinogenic impurities. This production process has completely independent intellectual property rights and is the world's first." In 2009, when the H1N1 virus hit again, the team once again miraculously: increased drug production capacity by 30 times, completed 26 million national reserve tasks in only 135 days, and saved 5.7 billion yuan for the country. In the following years, they developed the world's only oseltamivir granules for children, and newborns born more than 14 days can be used safely and safely. The successful development of peramivir injection has changed the predicament of the global flu-free patients with no medicine. The reporter learned that from capsules, granules to injections, from the world's first process to the establishment of the world's largest production capacity line, China has become one of the countries with the most abundant anti-influenza drugs and the strongest clinical treatment support capacity. The ability of independent prevention and control of scale flu has got rid of the predicament that prevention and control drugs cannot be bought, can not afford, and are under-purchased at critical moments. Oseltamivir phosphate is an excellent example of the company's ability to fight for technological innovation in the name of “surprise for the army and for the countryâ€. The reporter obtained such a set of data: the institute has successively walked out seven academicians of the two academies, and won more than 190 high-level scientific and technological achievements awards represented by the National Science and Technology Progress Special Award and the first and second prizes, and obtained 74 new drug certificates and patents. Authorized more than 500 items. (Reporter Zhang Qiang) Ungrouped,High Quality Ungrouped,Ungrouped Details, CN Shenzhen Guangyang Zhongkang Technology Co., Ltd. , https://www.syztreatment.com