Release date: 2014-06-16

In recent years, a large number of revolutionary technological innovations have brought about earth-shaking changes in the medical field. Recently, a foreign report based on the current medical market in 2009-2014 lists 10 new medical technologies with huge growth potential, such as capsule endoscopy, drug delivery systems, molecular diagnostics and targeted therapy, mobile medical, etc. The valuation is as high as $454.3 billion. In this issue, we selected six of the most promising technologies, and invited Liu Side, deputy director of the Department of Gastroenterology, Southern Hospital of Southern Medical University, and Yu Changxuan, deputy director of the Department of Oncology, Southern Hospital of Southern Medical University, and deputy director of the Department of Orthopaedics, People's Liberation Army General Hospital. Zhang Lihai, director of the traumatized area, Liu Qingjun, deputy director of the Department of Biomedical Engineering of Zhejiang University, and Liu Fan, assistant to the dean of Peking University People's Hospital and director of the information center, interpret and look forward to it.

Image diagnosis, relieve pain

Representative: Capsule endoscopy

According to reports, 2/5 (about 177.8 billion US dollars) of the top ten medical new technologies have market share from medical diagnostics, including nuclear medicine imaging and capsule endoscopy.

According to a report released by Frost & Sullivan Consulting, the medical imaging technology has shortened the imaging time to a few seconds in the past decade. The images are three-dimensional and full-color, which can largely replace the past biopsy. . For example, nuclear medicine imaging technology lays the foundation for non-invasive examination of liver fibrosis; capsule endoscopy protects patients from pain. Liu Side said that the capsule gastroscope is slightly larger than the ordinary capsule and has a large rice camera. After swallowing, it takes a picture at two speeds per second and sends the photo to the external image recorder in real time, with the stool discharged after 6-8 hours. The doctor can analyze the collected photos to see the status of the gastrointestinal tract at a glance. "Capsule gastroscope even realizes home inspection, and then sends photos to doctors with mobile phones and computers, it may be early detection of stomach cancer, etc." But it also has drawbacks, such as 50,000 photos taken in 8 hours, 70% is not Diagnostic value, and there is a blind spot. These problems need to be solved by manufacturers and doctors.

Molecular diagnosis, localization of cancer

Representative: Molecular Targeted Therapy

The top science journal Nature Genetics listed molecular diagnostics as the top of the top ten health technologies a few years ago. It plays a huge role in the prevention, diagnosis and individualized treatment of genetic diseases, infectious diseases and tumors.

Taking tumors as an example, the Global Cancer Report 2014 issued by WHO pointed out that in 2012, the number of cancer deaths in China was 2.2 million, accounting for 26.8% of the global total. The therapeutic effect of cancer patients in China is still not satisfactory. The solution is to improve early diagnosis and precise treatment of advanced tumors. You Chang Xuan said that about 80% of lung cancer patients were in advanced stage and lost their chance of surgery. Traditional chemotherapy is a "trial and error treatment", often choose a chemotherapy regimen according to the guidelines, evaluate the curative effect after 2 cycles of treatment, continue the original plan if it is effective, and change the plan if it is invalid. This mode has poor efficacy and side effects. You Changxuan said: "Research shows that the occurrence and development of tumors are often related to genetic abnormalities. For example, lung cancer, especially lung adenocarcinoma, has specific driving genes. To clarify the driving genes, molecular diagnosis is needed to help." The gene, given targeted molecular targeted therapy, has good curative effect and small side effects. For example, patients with advanced lung cancer carrying EGFR-sensitive mutant genes are given EGFR-TKI (such as gefitinib, erlotinib, etc.) targeted therapy, the disease control rate can reach 90%, patients do not need hospitalization, and the quality of life is very high. Many pharmaceutical companies have therefore joined the field, and the molecular diagnostics market has grown at an annual rate of 15% to 18%.

Minimally invasive technique to reduce wounds

Representative: minimally invasive internal fixation

In 1987, French doctor Murray completed the world's first laparoscopic cholecystectomy, creating a new era of minimally invasive surgery. For decades, from gastrointestinal endoscopy to laparoscopy, the concept of minimally invasive surgery has penetrated into various medical fields. Some foreign scholars have referred to minimally invasive surgery, genetic engineering, and organ transplantation as the three mainstreams of medical development in the 21st century.

Orthopedic minimally invasive techniques are leading the way. Taking the most common intertrochanteric fractures in elderly patients with osteoporosis as an example, Zhang Lihai said that in the past, dynamic hip screws were used, which was fixed by “plate-making”. The wounds were large, and patients needed to stay in bed for a long time, which easily induced thrombosis. "In our hospital statistics, the perioperative mortality of hip fractures in the elderly is about 6%, even higher than that of malignant tumors." Subsequently, the development of minimally invasive devices such as gamma nails overcome the problem of large surgical incisions, but can not hurt the bones. Complete reset. In this regard, Tang Peifu, dean of the Orthopaedic Hospital of the General Hospital of the People's Liberation Army, designed the medial support intramedullary nail and added a fixation to the inside of the injured bone by minimally invasive internal fixation. This technology allows patients to avoid death complications early, and is certified and approved by the State Food and Drug Administration and promoted in China.

Drug delivery system, on-demand

Representative: Nanocrystal technology

Foreign reports show that drugs with drug delivery systems (DDS) have a market share of about $110.8 billion. Early studies of DDS focused on slow-release formulations, allowing patients to stay for a longer period of time with a single shot. For example, leuprolide acetate microspheres, triptorelin microspheres, and risperidone microspheres are widely used in the treatment of tumors, metabolic diseases, and psychosis.

In recent years, the main goal of DDS research has been to compensate for bioavailability defects caused by the chemical structure of the drug itself. For example, the intestinal retention technology developed by AvMax in the United States allows the drug to stay in the small intestine with the best bioavailability, maintain the effect on Helicobacter pylori, and treat peptic ulcer. Elan's nanocrystal drug delivery technology contains an excipient that prevents aggregation and improves dissolution, solves the problem of timing administration, synchronizes drug delivery with human rhythm, and maintains a 24-hour balanced blood level. It has produced effects in the treatment of hypertension. Recently, Stephen Morton of the Massachusetts Institute of Technology developed a dual-drug, time-lapse nano-delivery system for cancer treatment to prevent cancer cells from resisting chemotherapeutic drugs. It can be seen that nanotechnology is an important direction for the development of DDS.

Non-invasive testing, replacing puncture

Representative: saliva detects blood sugar

Blood, amniotic fluid, bone marrow... The indicators of these fluids are the basis for the diagnosis of many diseases. But getting them requires puncture and is invasive, not only causing pain to the patient, but also easily cross-infecting. People with diabetes need to monitor blood glucose without interruption, and treatment compliance is poor.

The development of non-invasive detection devices based on biosensor technology brings hope to patients. According to a report by the American Society of Physicists in 2012, scientists at Purdue University in the United States have invented a sensor that can detect diabetes through tears and saliva, as well as diagnose Parkinson's disease and Alzheimer's disease. Dr. Mary Norton, deputy director of the Department of Clinical and Translational Genetics at the University of California, San Francisco, developed a non-invasive prenatal screening technique that detected more than 80% of common chromosome triploid abnormalities (such as Down's syndrome) and is expected to replace the fluff. Membrane sampling and amniocentesis.

With the development of wearable medical treatment, non-invasive detection technology is expected to enter thousands of households and achieve round-the-clock monitoring. For example, Israel BIG developed a watch-type blood glucose monitoring device to monitor the condition by measuring changes in bioelectrical resistance. However, the American technology magazine "Collecting the World" proposed that non-invasive blood glucose testing technology is still in the early stage of development and there is no product on the market. Liu Qingjun said that how to ensure more accurate data and more reliable analysis is a technical problem faced by such equipment.

Mobile medical care, security

Representative: Hospital Informationization

An American doctor sitting in the office can view the ECG of a Chinese patient through a wearable device. This is a bright prospect for mobile medical care. Eric Top, a famous American cardiologist, listed it as the most promising new medical technology.

The advantage of mobile medical care is that the patient is the core, to maximize the quality and safety of medical care, while improving efficiency. Liu Fan said that when infusion or medicine, the nurse uses the mobile PDA to scan the barcode on the patient's wristband and medicine respectively. If it matches, the words “execution success” will pop up, otherwise “patient and doctor's mismatch” will be given. "Medical doctor does not exist" and other tips to achieve zero error in medication. In addition, Peking University People's Hospital has a daily outpatient volume of over 10,000, and it takes more time for patients to queue up for payment. After investigation, it was found that about 25% of patients use bank cards every day, so the hospital is equipped with 7 mobile toll collection cards to reduce the queue time.

According to a report released by the Global System for Mobile Communications, the development of the mobile medical market in 2017 will bring in $23 billion in revenue. Mobile medical care will play a role in chronic disease management and personalized medicine.

Source: Life Times

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Step 2: Connect your PoE NVR to the LAN port of the router.Step 3: Open the monitor of your NVR, then select Channel Settings > IP channel. Check Auto Add and click Scan. Then the WiFi camera will show up in the list. Assign a channel for it if necessary.
NVR WiFi cameras can be added to NVRs if they are in the same LAN. Here we'll guide you to finish this process following the steps below.Step 1: Connect the camera to your router via WiFi by configuring WiFi settings for the WiFi camera.
Step 2: Connect your PoE NVR to the LAN port of the router.Step 3: Open the monitor of your NVR, then select Channel Settings > IP channel. Check Auto Add and click Scan. Then the WiFi camera will show up in the list. Assign a channel for it if necessary.
NVR WiFi cameras can be added to NVRs if they are in the same LAN. Here we'll guide you to finish this process following the steps below.Step 1: Connect the camera to your router via WiFi by configuring WiFi settings for the WiFi camera.
Step 2: Connect your PoE NVR to the LAN port of the router.Step 3: Open the monitor of your NVR, then select Channel Settings > IP channel. Check Auto Add and click Scan. Then the WiFi camera will show up in the list. Assign a channel for it if necessary.

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