Science Supplement: Nanomedicine can treat heart disease January 25, 2018 Source: Biological Exploration of: apprehension In recent years, nanoparticles have been used in drug delivery systems to deliver drugs to specific parts of the body. This therapy is usually given orally or intravenously, but often the heart drug delivery is inefficient. To this end, researchers have developed an inhalable nanomedicine that allows them to reach the heart faster and be absorbed by cardiomyocytes, ultimately improving heart function. The new inhalable nanomedicine was developed by researchers in Italy and Germany to treat heart disease patients. The results of a detailed study describing the development of inhalants, methods of use, and effects of animal experiments are published in Science Translational Medicine. The team used nanoparticles similar to teeth and bones - "calcium phosphate particles" to make nanoparticles that are small enough to be absorbed by heart tissue, large enough to transport the drug to a designated location. The study selected drugs that repair calcium channels on the surface of heart cells, and repairing calcium channels is considered to be the most critical part of restoring normal ECG activity. DOI: 10.1126 / scitranslmed.aan6205 After the drug was loaded on the nanoparticles, the team gave it to the heart-damaged mice and rats in a way that mimicked diabetic cardiomyopathy, and then measured the health of the heart by observing how much blood was expelled from the left ventricle. It was found that heart-damaged mice were 17% lower than healthy mouse heart scores prior to dosing. After treatment, the measured value increased by an average of 15%, and this is a state of near complete recovery. The researchers were very satisfied with the results of the study in rodents, and subsequently tested the pig's respiratory system (which has a more respiratory system similar to humans) and wondered how fast the drug is enriched in heart tissue. It was found to be as fast as expected and improved over traditional methods. The team also reported that inhalation of nanoparticles does not cause any toxicity to heart tissue in mice or rats. Of course, more research is needed to ensure that the delivery system is safe before testing in the human body. References: 1) A nanoparticle inhalant for treating heart disease Medical Nitrile Gloves,Nitrile Gloves Medium,Aql2.5 Industrial Gloves,Disposable Medical Nitrile Gloves Puyang Linshi Medical Supplies Co., Ltd. , https://www.linshimedicals.com
