A biopsy method that is more suitable for brain tumors has a new discovery that genetic material can accurately represent the tumor genome. January 28, 2019 Source: Science and Technology Daily Author: Zhang Meng Ran According to a recent publication by Nature in the United Kingdom, American cancer experts report a newly discovered genetic material that accurately represents the tumor genome. The researchers say that the detection of tumor-derived DNA in this cerebrospinal fluid (CSF) can be used to track the progression of some gliomas. This liquid biopsy method can be used as a minimally invasive method to replace brain tissue sampling. Glioma is the most common cancerous brain tumor in adults. Monitoring glioma progression may require repeated biopsies because the glioma genome will evolve over the course of disease development. The use of liquid biopsy (rather than biopsy of brain tumor tissue removed during surgery) is an attractive method for analyzing tumor DNA, but it has been challenging to detect this genetic information in blood samples. This time, the American Memorial Sloan-Kettering Cancer Center scientist Inge Melinhoff and colleagues demonstrated that cerebrospinal fluid can provide a more comprehensive source of tumor-derived DNA for patients with glioma. The team used a lumbar puncture to sample the cerebrospinal fluid of 85 glioma patients. In nearly half (42 patients), tumor-derived DNA was detected, which correlates with tumor size, progression, and disease prognosis. The researchers found that patients with cerebrospinal fluid containing circulating tumor DNA were four times more likely to die than patients without such DNA. Scientists have pointed out that genetic material found in cerebrospinal fluid can accurately represent the tumor genome; this liquid biopsy is used as a minimally invasive method to replace brain tissue sampling, can be used for disease grading, and help guide the treatment of glioma patients. In addition, they point out that not all gliomas will release DNA into the cerebrospinal fluid, but the presence of tumor-derived DNA may be an early indicator of brain tumor progression. YT-H706 YT-H706 Shenzhen Sunshine Technology Co.,Ltd , https://www.szyatwin.com