Recently, the world's top academic journal Nature has reported on the important research progress of the molecular mechanisms of genetic compensation effects by Professor Chen Jun and Professor Peng Jinrong of Zhejiang University. For the first time, the research team revealed that the gene compensation effect is triggered by messenger ribonucleic acid (mRNA) carrying a premature stop codon and is involved by upstream frameshift protein 3a (Upf3a) in the nonsense mutant mRNA degradation pathway (NMD). At the same time, it was revealed that the homologous sequence nucleic acid is a necessary condition for up-regulating the compensatory effector gene, and further studies have shown that the increase in the transcription level of the compensatory effector gene is caused by the epigenetic modification of the histone in the promoter region of the compensatory gene. The study provides new ideas for the treatment of the disease. Fig. Model of the GCR. EJC, the exon-junction complex. The discovery of the molecular mechanism of genetic compensation effects is of great significance for the treatment of diseases: The genetic compensation effect is not unique to zebrafish and is also present in model organisms such as mice and Arabidopsis. "The molecular mechanism we have discovered not only has important theoretical significance, but also has important value for revealing gene function research and disease treatment." Chen Jun introduced that "genetic compensation effect" is of great significance to the survival of the body, but for gene function research. It is a huge obstacle. For example, more than 80% of zebrafish genes are not phenotype after being knocked out, so it is difficult to study the function of these genes, most of which are caused by the "genetic compensation effect". In the future, if you want to study these genes, you can use the molecular mechanism revealed by Chen Jun's research group to knock down the "intermediate" protein Upf3a and block the genetic compensation effect to carry out genetic research. Genomic sequencing results show that there are a large number of genes carrying homozygous nonsense mutations in the genome of normal people, and some of them have missense mutations that cause serious human genetic diseases such as Parkinson's disease, leukemia, scoliosis and so on. Chen Jun's team speculates that this may be caused by genetic compensation effects. He said that human genetic diseases caused by missense mutations can be activated by knocking out the gene or transferring homologous DNA with nonsense mutations. The "genetic compensation effect" in the human body treats diseases. Anonymous review experts from Nature said in the review that this is an extraordinary story with a wide range of potential implications. For example, it clarifies the interpretation of many knockout studies. It provides a mechanism for an interesting phenomenon that gives the cell robustness. As the authors point out, the introduction of nonsense mutations may be a clinical approach to the treatment of genetic diseases with compensatory genes. In addition, we are about to participate in the International Zebrafish Conference held in Suzhou in June 2019. Interested children's shoes can be contacted at the show! Past exciting content: Huaan antibody helps scientists renew new literature in zebrafish basic research Huaan Bio-Recycling Good News passed the national high-tech enterprise certification The 2nd "Hua'an Cup - Dandelion Award" award is about to be revealed. Come and see if you have it. Recruiting talents Huaan Bio invites you to join Customer Mol Cell re-issues a new paper on the regulation of autophagy regulation gene Pacer regulation of autophagosome maturation and lipid metabolism Literature Sharing The latest article by Zhang Zhigang of Shanghai Jiaotong University reveals that CTHRC1 may play a new role in liver fibrosis or may become a new target for liver fibrosis research. About Huaan Hangzhou Huaan Biotechnology Co., Ltd. was established in 2007 and is headquartered in Hangzhou, China. In 2017, it established a wholly-owned subsidiary in Shanghai, USA: HUABIO INC. Huaan Bio is committed to providing high quality antibody reagents and antibody services to researchers and industrial customers around the world. The company's product line includes more than 4,000 kinds of monoclonal antibody, polyclonal antibody, secondary antibody, protein / peptide, reagents for antibody detection. 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Foreword:
Deoxyribonucleic acid (DNA), the genetic material in life, is constantly threatened by damage. Each cell's genomic DNA encounters about 10,000 damages per day. Genetic mutations caused by these damages can cause the genes encoding the proteins to lose their function, which in turn affects the meaning of life. In order to survive, life has evolved many ways to deal with genetic mutations, one of which is the " genetic compensation effect ." However, little is known about the molecular mechanisms by which the scientific community works for genetic compensation effects.
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Important Research Progress of Molecular Mechanism of Genetic Compensation Effect——Resolving the Mystery of Non-meaning Mutation of Life Response Gene
Great news: Nature's essay--scientists crack the mystery of life-insensitive genetic mutation