Pharmacological effects Studies have shown that absorption, distribution, and excretion of berberine are not easily absorbed by the oral route. Parenteral administration, rapid absorption into the tissue after entering the blood, blood concentration is not easy to maintain; human blood concentration of 100μg% (in vitro bactericidal concentration of approximately 20mg%) 30 minutes after oral administration of 0.4g berberine hydrochloride, and then gradually reduce, even if repeated Dosing, 0.4g every 4 hours, no increase in blood concentration. In vivo, berberine is distributed in almost all tissues, with most of them being heart, kidney, lung, and liver. Its retention time in each organization is very short-lived. After 24 hours, there are only a few traces. It is mainly metabolized in the body, and a small amount (6.4%) is excreted through the kidneys. After oral administration, rabbits can also absorb and stay in the blood for 72 hours. The urine is also excreted. The tissue has the highest concentration in the heart, followed by the pancreas and liver. Rats take orally, with little absorption. For injection, it mainly enters heart, pancreas, liver, and omentum fat; after 24 hours, only pancreatic and fat can still see a considerable amount of berberine. Only a small amount (1%) is excreted from the urine. Anti-pathogenic microorganisms Antibacterial activity Staphylococcus aureus, hemolytic streptococcus, pneumococcus, meningococcus, dysentery bacillus, anthrax bacilli and so on. Antiviral effects inhibit influenza virus, hepatitis B virus and so on. Antiprotozoal action inhibits amoeba, vaginal trichomoniasis, and trypanosomes in vitro. Effects on the cardiovascular system First, influence 1, anti-arrhythmia Berberine is an effective ingredient. Coptis - Herbal Medicine Pieces Coptis - Herbal Medicine Pieces Mechanism of action 1 Extended action potential duration and effective refractory period. 2 Inhibit sodium channels, slow down conduction, and eliminate reentry. 3 Inhibit calcium influx. 4 Anti-free radical damage, protect the cell membrane. 2, antihypertensive effect Berberine is an effective ingredient. Function characteristics 1 The diastolic blood pressure drops significantly and the pulse pressure difference increases. 2 No rapid tolerance. 3 Increased limb and visceral volume during decompression. The mechanism of action competitively blocks alpha-receptors, reduces peripheral resistance, and slows heart rate. 3, positive inotropic effect Active ingredient: Berberine. Performance: The heart is excited, the myocardial contractility is enhanced, and the cardiac function is not affected by reserpine, propranolol, phentolamine, and the vagotomy. Second, the mechanism of action: 1. Stop the K+ outflow. 2. Increase intracellular Ca2+ concentration. 3. Inhibit the production of free radicals and reduce the damage of myocardial cells caused by lipid peroxides. 4, reduce myocardial oxygen consumption. Detoxification Antibacterial toxins reduce Staphylococcus aureus coagulase, hemolysin titer and reduce the virulence of E. coli. Anti-inflammatory, antipyretic 1, inhibit a variety of experimental inflammation, the active ingredient is berberine, anti-inflammatory mechanism and stimulate corticosteroid release. 2. Antipyretic effects are related to the inhibition of neuronal cAMP production in the central PO/AH region. Inhibition of platelet aggregation First, the active ingredient: Berberine. Second, the mechanism of action 1. Inhibit the production of TXA2 in platelets. 2. Inhibiting the release of arachidonic acid from the platelet membrane and affecting its metabolism. 3, inhibition of extracellular calcium inflow. Drug safety Coptis and Berberine are safe for oral administration. The mice received intraperitoneal injection of Ber LD50 of 24.3 mg/kg. The valve is a series of gas emergency shut off solenoid valves, specially designed as gas pipe breaker for emergency use. It can be connected with gas leaking detection sensor, fire alarm circuit or other intelligent sensor modules so that on site or remote shut down on gas supply (manually or automatically) is possible, hence ensuring the safety on gas usage. The valve features an auto-close when strong vibration is detected. After close, manual operation is required to turn on the valve. This feature meets safety regulations in the event of an accident. Gas Solenoid,Solenoid Valve,Gas Solenoid Valve,Solenoid Operated Valve Rictron Industrial Co., Ltd , https://www.szrictron.com