Panasonic and the Belgian Microelectronics Research Center (IMEC) have jointly developed a fully automated small-scale genetic testing chip that can be tested in one hour. The chip can use several μL of blood to detect genetic information such as SNP (Single Nucleotide Polymorphism). SNP refers to the existence of different types of bases in different individuals' genomes. By detecting SNPs, it is possible to diagnose the risk of genetic diseases and future genetic diseases, and to identify genes associated with diseases. Most of the previous automatic genetic testing devices are large devices, and most of them adopt a method of sending samples to a specialized testing mechanism for analysis. Therefore, the test results will have to wait for several days to about one week to know. The chips developed this time are different, and it takes only one hour to complete the test, including the pre-treatment process. Therefore, at the clinical site, doctors can judge the patient's medication and the risk of on-the-spot on the spot. The chip developed this time integrates the function of extracting and amplifying DNA from trace blood for SNP judgment. Specifically, an ultra-small pump for transporting blood and a drug solution, a DNA extraction and amplification portion, a high-precision filter membrane, and a high-sensitivity sensor are integrated on a chip of about 9 cm 2 . The necessary technologies newly developed to implement the chip are roughly as follows: 1. High-speed PCR technology For genetic diagnosis, it is necessary to take out the SNP-containing region from the DNA and increase it to a certain amount. Generally, a method called PCR (Polymerase Chain Reaction) is used to amplify the DNA, but the original PCR It takes 2 hours to amplify the DNA. Therefore, the researchers used a silicon substrate with good thermal conductivity to optimize the means of isolating the surrounding heat, improving the temperature follow-up of the temperature rise and fall, and also realizing the structure of the PCR reaction by a small amount of liquid. By these measures, the time required to amplify the DNA is shortened to within 15 minutes. 2. High-precision, high-sensitivity electrochemical sensor When the SNP is electrically recognized, it is necessary to use an expensive special electrode in which the artificial DNA for identification is fixed to the electrode. With the newly developed sensor, it is not necessary to fix the artificial DNA for identification on the electrode, and the SNP can be electrically recognized in a state of being dissolved in a small amount (about 0.5 μL) of the drug solution. 3. Ultra-small high-pressure pumps using conductive polymer actuators By laminating a polymer film on a silicon substrate, a polymer actuator capable of greatly expanding and contracting in a lamination direction has been developed, and a diaphragm pump that transports a liquid by moving the separator is realized. The polymer actuator can generate pressures of up to 300 atmospheres, and it is easy to move the solution including the injection of liquid into the high-precision filter for screening DNA in the micro flow path. A battery-operated low voltage (1.5V) operation is also implemented. Dental Cleaner,Dental Cleaning Machine,Ultrasonic Dental Cleaner,Best Dental Ultrasonic Cleaner ZHEJIANG FOMOS MEDICAL TECHNOLOGY CO.,LTD. , https://www.ifomos.com